However, when examining two public mRNA profile datasets of LNCaP prostate cancer cells stimulated to profilerate with androgen treatment [27,28], myc was not found to be up-regulated (Chen dataset p = 0.53), and there was no enrichment for myc targets within genes inducted by R1881 in LNCaP (Chen dataset enrichment p = 0.10). This evidence concerns the gene MYC and Familial prostate cancer.