APOE and Alzheimer disease: Additionally, we found the following order for both PPVs and LRs+ of APOE alleles and genotypes with respect to the diagnosis of AD: ε4/ε4 > ε4 > ε3/ε4 > ε3 > ε2/ε4 > ε3/ε3 > ε2 > ε2/ε3 (see Table 3).