CXCL10 and neoplasm: The ELR+ molecules are generally considered pro-angiogenic, while the ELR- molecules are considered angiostatic[54] I-TAC has the highest affinity for CXCR3,[55] and rIFN-γ1b can upregulate the production of Mig, IP-10, and I-TAC[52] Tumor-associated MO/MAs have a range of effects that include both pro- and anti-inflammatory responses.