IRS1 and polycystic ovary syndrome: Reportedly, the allelic frequency of the 972Arg variant of IRS-1 was 0.11, and the allelic frequency of the 1057Asp variant of IRS-2 was 0.36 for PCOS individuals, and the Gly972Arg IRS-1 variant for PCOS individuals featuring a high fasting insulin was ten-fold greater than it was for PCOS patients exhibiting a low fasting insulin and 2.3-fold greater than for control women.