From our study, independently of whether patients featured NIDDM or not, the results also revealed no evidence of any polymorphism in the regions encoding codon 972 of the IRS-1 for the Taiwanese population, although 36.2% of our PCOS subjects revealed AGT and 72.3–87.2% revealed either insulin resistance or AGT with respect to different criteria of insulin resistance. The gene discussed is IRS1; the disease is polycystic ovary syndrome.