The increased level of IGFBP-3 was associated with increased pro-apoptotic proteins and apoptosis in response to quercetin, suggesting it may be mediated via its modulation of the Bax: Bcl-2 protein ratio and hypothesize that IGFBP-3 act as an effector of quercetin induced-apoptosis in prostate cancer cells. Here, BCL2 is linked to Familial prostate cancer.