Studies by Rajah et al [12] in prostate carcinoma cells and IGFRI-negative mouse fibroblasts showed an induction of apoptosis by both exogenous and endogenous IGFBP-3 and provide the strongest evidence of an IGFRI-independent pro-apoptotic role for IGFBP-3 in cancer cell growth. Here, IGFBP3 is linked to prostate carcinoma.