IGFBP3 and breast carcinoma: High levels of recombinant nonglycosylated IGFBP-3 can induce apoptosis in MCF-7 breast carcinoma cells, although under some conditions these levels of exogenous IGFBP-3 may induce apoptosis indirectly by sequestering anti-apoptotic IGFs from the IGFRI [14].