Recently, anterior gradient protein-2 (AGR2; previously hAG-2), human homologue of the Xenopus laevis cement gland protein, XAG-2, has been identified, by suppression subtraction hybridisation, as being expressed at a higher level in the human breast cancer cell line MCF-7 than in the benign cell line Human mammary 123 (Liu et al, 2005). This evidence concerns the gene AGR2 and breast cancer.