As expected, the majority of the ERα-positive tumours were grades 1 or 2 (n=177) and within this subgroup staining for AGR2 was also associated with poorer patient survival (log rank test, P=0.009; Wilcoxon test χ2=5.8, 1 d.f.; P=0.02). The gene discussed is AGR2; the disease is neoplasm.