In the small number of patients with ERα-positive grade 3 tumours (n=43), there was a trend for AGR2 to be associated with poorer survival, but this did not reach statistical significance (log rank test, P=0.1; Wilcoxon test χ2=1.9, 1 d.f., P=0.2). The gene discussed is ESR1; the disease is neoplasm.