Considering the role of the PRKCA in regulating immune response of T cells and the fact that this locus on chromosome 17q was found to be one of the human non-HLA autoimmune clusters sharing conserved genetic location with animal autoimmune loci [38], it is tempting to speculate that PRKCA might also have a role in susceptibility to other autoimmune diseases, especially those mapping to the 17q24 locus, like rheumatoid arthritis and psoriasis. This evidence concerns the gene PRKCA and autoimmune disease.