SMAD7 and neoplasm: Indeed, several of the identified genes in our study are reported to be involved in angiogenesis, tumor angiogenesis and arteriogenesis, i.e. IL-8 [39], ET-1 [40], CARP [41], HPTPη [42], ID1 [43,44], MGSA [45], SMAD7 [46], HO-1 [47,48], RHOB [49], PTHLH [50,51], SERPINH1/HSP47 [52], JAG1 [53], GNA13 [54] and TEAD4 [55].