TYMS and malignant colon neoplasm: In this study, a systems biology approach was used to investigate genes altered by the overexpression of TS at both transcriptional and post-transcriptional levels using human genome expression array in TS-depleted human colon cancer HCT-C18(TS-) cells and HCT-C18 (TS+) cells stably transfected with the human TS cDNA expression plasmid.