However, over-expression of ZIP1 in RWPE2 cells made cells (Clone A & B) sensitive to the TRAIL-induced apoptosis (~90% increase, Fig. 8b), suggesting that an increase of intracellular zinc concentration via zinc uptake protein in malignant prostate epithelial cells may be useful for the treatment of prostate cancer. The gene discussed is SLC39A1; the disease is Familial prostate cancer.