However, over-expression of ZIP1 in RWPE2 cells made cells (Clone A & B) sensitive to the TRAIL-induced apoptosis (~90% increase, Fig. 8b), suggesting that an increase of intracellular zinc concentration via zinc uptake protein in malignant prostate epithelial cells may be useful for the treatment of prostate cancer. Here, TNFSF10 is linked to Familial prostate cancer.