The large majority of cases involving reactivation of latent M. Tb in patients treated with TNF antagonists appear to have occurred with infliximab (RemicadeTM; humanized monoclonal antibody) with ~144 and ~35 cases of tuberculosis per 100,000 patients occurring with infliximab and etanercept respectively from January 1998- September 2002 [15]. Here, TNF is linked to tuberculosis.