LEP and obesity due to melanocortin 4 receptor deficiency: Nonetheless, it is noteworthy that, while this mutation has been associated with various CAD risk factors such as obesity [2], rheumatoid arthritis [6], coronary events in elderly patients [7], elevated leptin and triglycerides levels [8] in different populations, currently there is hardly any data available in the literature implicating it in the manifestation of CAD.