Furthermore, no significant difference in either S100A8 or S100A9 expression levels was detected in non-airway tissue, including the ileum (tissue most severely affected in CF mice) or liver of CF compared to wild-type animals of both C57BL/6J and BALB/cJ strains (p ≤ 0.5, five mice for each group), as shown in Fig. 1C, indicating that increased levels of S100A8 and S100A9 expression were lung specific. This evidence concerns the gene S100A8 and cystic fibrosis.