Importantly, other cell types reported to have inducible expression (vascular endothelial cells and macrophage) were negative for S100A8 staining in B6-CF lungs (Figure 3K and 3L, respectively), indicating that its increased levels in whole lungs were not the effect of induction in such cells, but exclusively due to the increased numbers of expressing neutrophils. Here, S100A8 is linked to cystic fibrosis.