While secretory diarrhoea is caused by a direct effect of toxins on epithelial ion transport, mainly via cAMP mediated activation of luminal CFTR and the associated inactivation of ENaC, studies indicated that intestinal ion transport in inflammatory diarrhoea is changed by effects of inflammatory mediators on CFTR, ENaC and Na/K ATPase. Here, CFTR is linked to Secretory diarrhea.