No correlation was found in the expression patterns of ADAMTS-8, TSP1 and VEGF. It has been shown that VEGF is significantly overexpressed in GBMs (Plate et al, 1992; Shweiki et al, 1992), meningiomas, metastases and haemangioblastomas, however our data indicated up-regulation of VEGF in only 38% of tumours. The gene discussed is THBS1; the disease is neoplasm.