In contrast, ADAMTS-4 (aggrecanase-1) and TS-5 (aggrecanase-2) are upregulated in glioblastomas (GBMs), with a possible role in increased degradation of brevican thereby increasing invasive potential (Nakada et al, 2005; Held-Feindt et al, 2006). The gene discussed is ADAMTS4; the disease is glioblastoma.