ADAMTS8 and neoplasm: Most of the tumours (24 out of 35, 69%) showed some positive diffuse cytoplasmic staining for ADAMTS-8, with the exception of two mucinous-type metastases of gastrointestinal origin that showed focal punctate cytoplasmic staining similar to that seen in cerebellum, uninvolved brain, stomach and normal lung (Table 1)(Dunn et al, 2004).