It was recently demonstrated that adiponectin stimulates JNK activation in prostate cancer (DU145, PC-3 and LNCaP-FGC cells), hepatocellular carcinoma (HepG2) cells and C2C12 myoblasts, but also drastically suppresses STAT3 activation in DU145 and HepG2 cells, in which STAT3 is constitutively activated (Miyazaki et al, 2005). This evidence concerns the gene STAT3 and Familial prostate cancer.