The known ARVC loci on chromosomes 14q23-q24 (ARVC1), 1q42-q43 (ARVC2), 14q12-q22 (ARVC3), 2q32.1-q32.3 (ARVC4), and 3p23 (ARVC5) were excluded as disease loci in this family (data not shown). This evidence concerns the gene RYR2 and arrhythmogenic right ventricular cardiomyopathy.