This correlation of BHRF1 miRNA cluster expression and Cp/Wp promoter usage suggests that the BHRF1 miRNAs are actually processed out of the BamHI H intron present in the very long EBNA pre-mRNAs that are transcribed from the Cp and Wp promoters and not, at least during latent infection, from mRNAs encoding BHRF1. We therefore propose that expression of the EBV BHRF1 miRNA cluster is likely to be a characteristic of type III EBV latency. The gene discussed is CP; the disease is disease arising from reactivation of latent virus.