PRRT2 and infection: Interestingly, inhibition of the phosphorylation of endogenous PKC substrates was also observed after transfection of neurons with BDV P. P, a cofactor for the viral polymerase complex, is abundantly expressed in the CNS following infection and was previously shown to be phosphorylated by PKC [38], consistent with our findings that P is phosphorylated at serine residues following PMA treatment.