Tumorigenesis studies have demonstrated that PDK1-expressing mouse mammary epithelial cells (Comma/PDK1) form adenocarcinomas in syngeneic mice [13], and that transformation was related to increased expression of PKCα and β-catenin activation, and to downregulation of the breast tumor suppressor caveolin-1 [13,14]. This evidence concerns the gene PDK1 and breast neoplasm.