DOX, ETO, VIN and TAX (but not CDDP) induced a modest increase (2 to 4-fold) of caspase-3/7 activity in the 2 breast carcinoma cell lines, while these 5 drugs (except CDDP in 4 NHL) almost consistently increased (up to 28-fold) caspase-3/7 activity in the 5 NHL cell lines tested (Table 4). Here, CASP3 is linked to non-Hodgkin lymphoma.