Co-culture with CD40L L cells also reduced the percentage of cells undergoing apoptosis in 4 of the 6 RCC cell lines exposed to DOX (-44% to -70%) and, marginally, in the HCT116 colon carcinoma cell line (-15%) and prostatic carcinoma cell line HTB-81 (-30%). The gene discussed is CD40LG; the disease is renal cell carcinoma.