CASP3 and breast carcinoma: For the two breast carcinoma cell lines T47D (Figure 3B), and BT20 (not shown) however, exposure to CD40L L cells did not significantly affect the balance of the 89 kD and 113 kD forms of PARP protein,; this observation is consistent with the absence of modulation of caspase-3 activity in the 2 breast carcinoma cell lines.