We applied the DDRT-PCR method to discover genes involved in tumorigenesis of human cervical tissue, and identified the new human cervical cancer-related gene, proliferation-inducing gene 2 (PIG-2) (GenBank accession number AY232290), which exhibits close similarity to gremlin 1 cDNA (GenBank accession number NM_013372) in the database. Here, GREM1 is linked to cervical cancer.