GREM1 and neoplasm: They also demonstrated that overexpression of Drm in the tumor-derived cell lines Daoy (primitive neuroectodermal) and Saos-2 (osteoblastic) significantly inhibited tumorigenesis and provided evidence that Drm can function as a novel transformation suppressor and suggested that this may occur through its affect on the levels of p21Cip1 and phosphorylated p42/44 MAPK [14,35].