The XRCC1 280His allele was associated with an increased risk of adenomas with OR of 2.30 (95% CI 1.19–4.46) (OR 3.82, 95% CI 1.59–9.18 and OR 2.07, 95 % CI 1.05–4.10 for high- and low-risk adenomas, respectively). Here, XRCC1 is linked to adenoma.