Based on the observed non-linear over-expression of MX1 mRNA and p78MX1 protein in senescent fibroblasts with +21, and the over-expression of p78MX1 in inflamed hair follicles of alopecia areata, hyperactive interferon signaling is a candidate pathway for cell senescence and autoimmune disorders in DS. Here, MX1 is linked to alopecia areata.