NR3C1 and breast carcinoma: For inhibition of apoptosis a functional glucocorticoid receptor (GR) is required and association with the transcriptional induction of survival molecules like serum and GC-inducible protein kinase-1 (SGK-1) and mitogen-activated protein kinase phosphatase-1 (MKP-1) is suggested in human established breast cancer cell lines [15].