In studies from Finland and the Netherlands the CHEK2 1100delC has been reported at frequencies of 1.6–2.6% among individuals with colorectal cancer, which is not significantly higher than in unaffected individuals from the population, but these studies may be compatible with a risk of 1.5–2.0 for development of colorectal cancer among carriers [14-16]. This evidence concerns the gene CHEK2 and colorectal cancer.