MKI67 and neoplasm: In terms of assessing proliferation status with Ki-67 scores, we have analysed results in three ways: (i) comparison of tumour scores at individual time points grouped according to response status at 3 months, (ii) classifying a >40% change in Ki-67 between different time points as evidence of a meaningful change in proliferation and (iii) comparing the number of cases in which proliferation is reduced to <1%, a value that we have regarded as a state of virtual non-proliferation.