We also attempted to study when in the transformation process that cyclin E begins to appear in parallel with cyclin A. Tissue samples containing everything between normal or inflamed epithelium to invasive squamous carcinoma, including cervical intraepithelial neoplasia (CIN) and carcinoma in situ lesions, from 11 different patients were studied. The gene discussed is CCNA2; the disease is cervical squamous intraepithelial neoplasia.