TIMP2 and gastric cancer: As TIMP-2 immunohistochemical staining combined with in situ hybridisation experiments detected the expression of TIMP-2 in gastric cancer tissue, primarily in peritumoral stromal cells rather than in malignant cells (Joo et al, 2000), we conclude that the localisation of TIMP-2 within the cancerous tissue might be of crucial importance but apparently not the total amount of the inhibitor.