Re-expression of sFRP1 in the colorectal cancer cell line HCT116 led to a reduction in nuclear β-catenin (Suzuki et al, 2004), while inhibition of WNT1 signalling by a function-blocking antibody caused apoptosis in primary colorectal cancer cells and cell lines (He et al, 2005). Here, WNT1 is linked to colorectal cancer.