Antidepressants may affect the risk of breast cancer through the influence of prolactin, of which elevated levels have been observed with use of SSRIs, tricyclic antidepressants, and other psychotropic drugs (Amsterdam et al, 1997; Cowen and Sargent, 1997; Emiliano and Fudge, 2004). The gene discussed is PRL; the disease is breast carcinoma.