PTGS2 and neoplasm: Therapeutic blockade of PGE2 production using COX inhibitors such as NSAIDs or specific COX-2 inhibitors such as celecoxib, rofecoxib and NS-398 have shown potential to inhibit both tumour growth and metastasis in experimental animal models (Dandekar and Lokeshwar, 2004; Patel et al, 2005).