LAMB2 and LOC syndrome: Mutations in laminin genes have been identified in several human disorders: muscular dystrophy (LAMA2; [4]), epidermolysis bullosa and Laryngo-onycho-cutaneous syndrome (LAMA3 [5,6]; LAMB3 [7]; LAMC2 [8], and microcoria-congenital nephrosis syndrome (LAMB2 [9]).