Genes responsible for the aphakia and dysgenetic lens phenotypes have been identified as transcription factors, Pitx3 and Foxe3; both genes were also shown to be involved in human ocular disorders involving abnormal lens, iris and corneal development [54,55] and zebrafish pitx3-morphants displayed lens degeneration similar to mammals [70]. This evidence concerns the gene FOXE3 and congenital primary aphakia.