For two genes C-reactive protein (CRP), a marker for inflammation and associated with susceptibility to SLE [14,15], and FCER1B, high-affinity receptor for immunoglobulin E (IgE) (MS4A2), located in the putative T1D locus IDDM4, and associated with atopic illness [16,17], we also carried out a re-sequencing effort, to gain a more comprehensive profile of allelic variation of the genes and their potential association with T1D. This evidence concerns the gene IGHE and type 1 diabetes mellitus.