Reduction of NFκB1 mRNA in RA bone marrow CD34+ cells by transfection of siRNA for NFκB1 markedly suppressed the generation of fibroblast-like cells as well as the production of MMP-1 and VEGF under the influence of TNF-α without affecting the viability or the capacity to produce β2MG. This evidence concerns the gene MMP1 and rheumatoid arthritis.