Consistently, whereas siRNA for NFκB1 inhibited the differentiation of RA bone marrow CD34+ cells stimulated with SCF, GM-CSF and TNF-α into fibroblast-like cells (Figure 13), it significantly influenced neither the viable cell numbers nor the levels of β2MG in the culture supernatants (Figure 14). The gene discussed is TNF; the disease is rheumatoid arthritis.