COX-2 over-expression in the spinal cord of patients with ALS has also been shown to be present in neurons and glial cells of the CNS [34] and some reports have shown that COX-2 immunoreactivity in normal rats is localised to neurons of laminae II-III, motoneurons of lamina IX and glial cells [6,35]. Here, PTGS2 is linked to amyotrophic lateral sclerosis.