ZAP70 and B-cell chronic lymphocytic leukemia: IgVH mutations and ZAP-70 expression have been reported to be among the most important prognosticators for B-CLL [5,8,14-16,28,40-42]; in this regard IgVH mutations below the established cut-off of 2% and expression of ZAP-70 in more than 20% of neoplastic cells had a negative impact on survivals also in our series [17].