TP53 and neoplasm: In this report, we hypothesize that this rare neoplasia originates from totipotent stem cells, located in the basal squamous layer of the dermoid cyst, and we present immunohistochemical evidence of aberrant expression of mesenchymal markers (vimentin and alpha smooth muscle actin), together with positive staining for CD10, P53 and P63, in some atypical basal squamous cells.