Several founder mutations of the breast and ovarian cancer susceptibility gene BRCA1 have been identified in individuals of many different ancestries, including families of Ashkenazi Jewish (187delAG, 5385insC) [1], French Canadian (C4446T, 2953del3+C) [2,3], Dutch (2804delAA and Alu-mediated deletions encompassing exons 13 and 22) [4,5], and Polish (5385insC, C61G, 4153delA) [6] origins. The gene discussed is BRCA1; the disease is ovarian cancer.