To evaluate the combined roles of MMP-2, MMP-3, and MMP-9 in the progression of renal disease inα3(IV)−/− mice, we treatedα3(IV)−/− mice with a combination of MMP-inhibitors to block MMP-2, MMP-3, and MMP-9 at the same time [27,28]. This evidence concerns the gene MMP3 and kidney disorder.