TM4SF4 and neoplasm: Other intestinal-type cell adhesion molecules included LGALS4, a member of the galectin family of carbohydrate-binding molecules (Huflejt and Leffler, 2004); three members of the transmembrane 4 (tetraspanin) superfamily (TM4SF4/IL-TMP, TM4SF5/L6H and TM4SF3/CO-029) associated with cellular proliferation, adhesion, motility, and tumour cell metastasis (Wright et al, 2000); and two members of the carcinoembryonic antigen family, CEACAM6 and CEACAM5 (CEA), frequently expressed by at least a subset of MOC (McCluggage, 2000).