The FDA recently approved two targeted agents: an antivascular endothelial growth factor (anti-VEGF) monoclonal antibody, bevacizumab and a human epidermal growth factor receptor (HER-1/EGFR) targeted monoclonal antibody, cetuximab as first and second-line metastatic colorectal cancer therapy, respectively (Venook, 2005). Here, EGFR is linked to metastatic colorectal cancer.