The increased expression of stearoyl-CoA desaturase-1 (SCD-1) plays a key role in lipogenic gene expression and in metabolic syndrome, which coincides with marked elevations of lipoprotein lipase (Lpl, 33-fold) and cytosolic acyl-CoA thioesterase-1 (Cte1, 5-fold) in arsenic-induced HCC. The gene discussed is ACOT1; the disease is hepatocellular carcinoma.