NFKB1 and melanoma: For instance, arsenite or ATO has been shown to induce apoptosis of melanoma and lymphoma cells by inhibiting NF-κB activity (Ivanov and Hei 2004; Mathas et al. 2003); however, ATO enhances CD95/Fas-induced apoptosis through NF-κB activation (Woo et al. 2004).