Increased risk of MS in women has been detected with interleukin-1 receptor antagonist (IL-1RA) allele 2 [11], 5G5G genotype of plasminogen activator inhibitor 1 (PAI-1) gene [10] and interaction between estrogen receptor 1 (ESR1) and HLA-DR2 [13]. This evidence concerns the gene ESR1 and myeloid sarcoma.