In the present study we found an increased staining for SA-β-Gal and a qPCR-confirmed upregulation of senescence-associated IGFBP-3 and IGFBP-rP1 in cultured primary parenchymal lung fibroblasts from patients with emphysema; this was supplemented by detection of higher protein levels of IGFBP-3. Here, IGFBP7 is linked to pulmonary emphysema.