On this respect, the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) has been postulated as a key player in the tumor microenvironment, but has a paradoxical role in disease evolution: It can act both as a necrotic or as a promoting factor [2] e.g., the endogenous TNF-α chronically produced in the tumor microenvironment enhances both tumor development and spreading, while local administration of high-doses of TNF-α is antiangiogenic and has a powerful anti-tumoral effect [3]. Here, TNF is linked to neoplasm.