Other studies have found that more that half of patients diagnosed with PC showed one of three molecular phenotypes: p27(+)bcl-2(-)Ki-67(+)mdm2(-) (9%), p27(-)bcl-2(-) Ki-67(-)mdm2(-) (27%), and p27(-)bcl-2(+)Ki-67(+)mdm2(-) (18%). Here, MDM2 is linked to pachyonychia congenita.