An elevated expression of CCN3 was associated with tumor differentiation and good prognosis in the case of Wilm's tumors, chondrosarcomas, osteosarcomas, neuroblastomas and chronic myeloid leukemia, whereas it was associated with an increased proliferation rate and/or metastases in the case of RCC, prostate carcinomas, and Ewings tumors [24,39,43,48-50]. Here, CCN3 is linked to Wilms tumor.