For the DDD category for the Minus subclone, there were 4 genes, all in our list of genes of special interest to the study of neutrophil differentiation in response to drug treatments for APL: C/EBP-gamma, which may cooperate with FOS to bind PRE-I enhancer elements; c-Myc, known to be down-regulated by retinoic acid; PCNA, and PPARBP (PPAR binding protein), which, along with TFIID, can activate the SP1 transcription factor, interact with thyroid hormone receptor, or function with p53 in apoptosis. This evidence concerns the gene SP1 and acute promyelocytic leukemia.